alexa The Role of Hypoxia-Inducible Factor/Prolyl Hydroxylation Pathway in Deoxycorticosterone Acetate/Salt Hypertension in the Rat

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The Role of Hypoxia-Inducible Factor/Prolyl Hydroxylation Pathway in Deoxycorticosterone Acetate/Salt Hypertension in the Rat

Data from this study suggest that reduced PHD2 expression and consequent increase in HIF-1α expression probably result from hypoxia induced by DOCA/salt treatment. This priming event was accompanied by hypertension or renal damage at later stages when the continued hypoxia, reduced PHD2 expression and increased HIF-1α expression were accompanied by hypertensive renal injury and collagen deposition. Despite the lack of additional effect on PHD expression, a protective effect of a known PHD inhibitor in DOCA/salt hypertension emerges by mechanisms that are in part related to increase NO and/or reduced reactive oxygen species production.

For More: https://www.omicsgroup.org/journals/the-role-of-hypoxiainducible-factorprolyl-hydroxylation-pathway-2167-1095-3-184.php?aid=35736

 
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