Several Single Nucleotide Polymorphisms (SNPs) in the Interleukin (IL)-28B gene are associated with Sustained Virological Response (SVR) to pegylated (PEG)-interferon (IFN) and ribavirin (RBV) in patients having Chronic Hepatitis C (CHC) genotype 1b and high viral load [1-3]. The mapped region (19q13) encodes 3 cytokine genes (IL- 28A, IL-28B and IL-29) that belong to the IFN-lambda (also known as type 3 IFN) family induced by viral infection and has antiviral activity .
Citation: Koji I, Kaori K, Mie S, Michio K, Masao S, et al. (2012) Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load. J Blood Lymph 2:109.