alexa The roles of Polycystin-1 and Polycystin-2 in cardiovascular function

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The roles of Polycystin-1 and Polycystin-2 in cardiovascular function

Autosomal Dominant Polycystic Kidney Disease (ADPKD) caused by mutations in polycystic kidney disease 1 or 2 (Pkd1 or Pkd2) gene is the most common inherited renal disease. This disease is characterized by the formation of fluidfilled cysts in the kidneys as well as cardiovascular abnormalities such as hypertension and aneurysms, which have emerged as a major cause of death in patients with ADPKD. Polycystin-1 (PC1) and polycystin-2 (PC2), encoded by Pkd1 and Pkd2 genes, respectively, are detected in the cardiovascular system, indicating that PC1 or PC2 may play an important role in cardiovascular function. Studies indicate the important functions of PC1 and PC2 in the development and homeostasis of cardiovascular system.

Source:  The Function of Polycystin-1 and Polycystin-2 in Cardiovascular System

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