alexa Measuring Platelet Reactivity after Clopidogrel-Has it Reached the End of the Road?

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Measuring Platelet Reactivity after Clopidogrel-Has it Reached the End of the Road?

Clopidogrel is traditionally prescribed at 75 mg daily after a 300 mg loading dose. It is a pro-drug, with a two-step activation process involving a series of cytochrome P-450 (CYP) isoenzymes. Its antiplatelet effect is variable and susceptible to genetic polymorphisms. In particular, patients with either 1 or 2 loss-of-function CYP2C19 alleles have an attenuated pharmacologic response and worse clinical outcomes with standard dose clopidogrel

 
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