alexa Bullous Pemphigoid Following Hepatitis B Vaccinations

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Bullous Pemphigoid Following Hepatitis B Vaccinations

Bullous Pemphigoid is an autoimmune blistering disease of the skin appears in both genders. It is a chronic disease characterized by spontaneous exacerbations and remissions. In adult BP include tense blisters that following rapture leave shallow erosions and in infantile BP the blisters tend to occur more frequently on the palms, soles, face and rarely affect the genital area. The autoantibodies participating in BP typically react with two selfantigens the BP 230 a cytoplasmic protein and BP 180 a transmembrane protein. Both antigens are part of the hemidesmosomes which belong to the dermo-epidermal adhesion complexes, promoting the adhesion in the epithelium. The etiology of BP is poorly understood and it has been associated with exposure to systemic drugs such as furosemide, phenacetin, amoxicillin and ciprofloxacin. In addition some reports are proposing the correlation of BP and vaccinations like influenza vaccines, diphtheria tetanus pertussis and fw of them following hepatitis B vaccination.




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