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Platinum agents are used today in combination therapy regimes with gemcitabine as second line chemotherapy for metastatic pancreatic cancer. Cisplatin (dis-diamminedichloroplatinum, CDDP, PtCl2(NH3)2) and is an inorganic platinum complex composed of a doubly charged platinum ion, and four ligands-two chloride ions and two amines. Cisplatin is a potent chemotherapy drug discovered in the 1960’s. It is widely used today against a variety of tumors including head and neck, non-small cell lung, stomach and bladder cancers, non-Hodgkin’s lymphoma and sarcomas
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