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Preeclampsia (PE) affects 5-8% of all pregnancies worldwide. It is a pregnancy-specific syndrome characterized by hypertension, proteinuria, edema as well as intrauterine growth restriction. The lack of reliable methods for early diagnosis prior to clinical onset limits the opportunities for prevention and timely treatment of PE. Moreover, there is no efficacious therapy except for delivery. Thus, PE contributes significantly to maternal, fetal and neonatal morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring.
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