Followed up 2500 singleton pregnancies, the incidence of trisomy 21 was 0.6% (16/2500) (95%CI 0.4- 1.0%). The absence of nasal bone and poly-malformation were the essential ultrasonographic findings of Down’s syndrome. An increased fetal NT (≥ 2.4 mm) related significantly to this aneuploidy (OR=58.6, 95%CI 17.3-251, p < 0.0001). In comparison of 4 approaches screening, the most possibility of Down’s syndrome detection was the combined test (87.5% of sensitivity for 2.6% of false positive rate).
Citation: Tomai XH, Schaaps JP, Foidart JM (2012) Evaluation of Trisomy 21 Screening by Fetal Nuchal Translucency Thickness, Maternal Age and Biochemical Serum in the South of Vietnam. Gynecol Obstet 2:122. doi:10.4172/2161-0932.1000122