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Hepatocellular carcinoma is the third leading cause of cancer-related death in the world. Glypican-3 (GPC3) is a member of the protein glycan family with a tissue-specific expression. They are released from cell surface and functional to regulate the cell signaling of migration, proliferation and cell survival.Glypicans regulate several signaling pathways such as Wnts, hedgehogs, fibroblast growth factors which could exert stimulatory or inhibitory effects on cells. In cells predominately controlled by hedgehogs signaling, GPC3 inhibits cell proliferation, whereas in cell predominately controlled by Wnt signaling pathway, GPC3 stimulates cell proliferation.GPC3 overexpression effectively inhibited proliferation, induced cell cycle arrest at S phase and increased apoptosis in Huh-7 cells. Furthermore, GPC3 overexpression significantly inhibited the migration and invasion ability of Huh-7 cells.
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