The present work studied the effect of Pyrethroid Insecticidefenvalerate on albino rats’ liver and possible ameliorative roles played by Propolis. In this study the Fenvalerate treatment has confirmed to induce many histological changes in the liver of albino rats including congestion of blood vessels, cytoplasmic vacuolization of the hepatocytes, necrosis and fatty degeneration. Biochemical results showed that fenvalerate caused marked elevation in serum ALT and AST. It also caused an increase in malondialdehyde and depletion in activity of the antioxidant enzymes, catalase and superoxide dismutase in the liver organ. Treating animals with fenvalerate and Propolis led to an improvement in both histological and biochemical alterations induced by fenvalerate. Moreover, Propolis was found to reduced the level of malondialdehyde and increased the activity level of antioxidant enzymes, SOD and CAT. These results indicated that Propolis ameliorated liver damage induced by fenvalerate and this could attribute to Propolis antioxidant activity and free radicals scavenging properties.