Chronic heart failure (CHF) is considered as a leading cause of morbidity and mortality in worldwide . Endothelial dysfunction has been shown to play a critical role in the clinical manifestations of CHF . Recent studies suggested that injure of endothelial monolayer due to any reasons leads to dramatic increase of circulating level of endothelial-derived apoptotic Microparticles (MPs) . MPs are a heterogeneous population of sub-micronic vesicles that are released in response to cell activationor apoptosis . It has been investigated that MPs represent an intercellular communication and delivery mechanism for the efficient and effective transfer of biological information, which selectively packaged as intracellular material included bioactive lipids, integrins, cytokines, enzymes, mRNA and micro-RNA that lead to reprogramming recipient cells; proatherogenic and pro-thrombotic effects; as well as modulating inflammatory response . Increase in circulating MPs is detectable in several cardiovascular diseases, such as acute coronary syndrome, atherosclerosis, dyslipidaemia, hypertension, stroke, atrial fibrillation, as well as sepsis, cancer, lupus erythematosus, chronic kidney disease, type two diabetes mellitus, obesity . While MP are sensitivity markers of endothelial dysfunction and tissue remodelling, they are also indicator of an imbalance between proangiogenic and anti-angiogenic responses, and they could be used to predict value in cardiovascular disease . We postulated that CD31+/annexin V+ MP might be discussed as prognostic factors in CHF, but their predictive value in patients with symptomatic ischemic CHF has not been defined. The aimof this study was to evaluate the potential prognostic value of circulating CD31+/annexin V+ MP for cumulative survival in patients with ischemic CHF.
Berezin AE, Kremzer A A, Samura TA, Martovitskaya YV (2014) Predictive Value of Circulating Apoptotic Microparticles in Patients with Ischemic Symptomatic Moderate-To-Severe Chronic Heart Failure. Angiol 2:121.