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Parkinson's disease (PD) is the most common movement disorder and second most common, after Alzheimer’s disease, neurodegenerative disorder in humans. It affects over one million people in North America and over four millions people worldwide and influences all races and both sexes. PD is defined clinically by four characteristic motor symptoms: uncontrollable resting tremor, slowness in movement (bradykinesia) and postural instability. Neuronal accumulation of a protein called alpha synuclein (α-syn) appears to be a critical step in the development of PD and other neurodegenerative diseases, collectively referred to as synucleinopaties. Genetic and biological studies support a role for α-syn in the pathophysiology of these diseases. Thereofore, research must be continued in order to better understand the functions of the synuclein proteins under normal physiological conditions as well as their role in disease.
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