Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Reprogramming of mRNA translation by localized alterations in the standard translational rules is termed as recoding. Frameshifting is one class of recoding and defined as protein translations that start not at the first, but either at the second (+1 frameshift) or the third (-1 frameshift) nucleotide of the codon. Apparently, most frameshifts would yield nonfunctional proteins. Therefore frameshifts lead to waste of energy, resources and activity of the biosynthetic machinery. In addition, some peptides synthesized after frameshifts are most likely cytotoxic. Coding sequences lack stop codons, but many stop codons generated due to frameshifted sequences, termed off-frame stops or hidden stop codons. These hidden stops terminate frame-shifted translation, potentially decreasing energy, and resource waste on nonfunctional proteins. Frameshift mutations for the sake of mitochondrial genomes were evaluated and results support this putative ancient adaptive event for the selection of codons that can be part of hidden stop codons. Mitochondrial genomic data analyses support this fact as most of the correlations between hidden stops and various functional and evolutionary parameters were positive. Association of frameshift mutations with many diseases is also being studied to represent the biological significance of this putative event. It is estimated that this kind of study will reveal momentous correlation between frameshift mutations and their biological consequences.
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi