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Renal cell carcinoma (RCC) is the most public cancer arising from the kidney in adults, with clear cell carcinoma (ccRCC) representing the majority of all RCCs. Expression of a human HIF1a triple mutant (P402A, P564A and N803A) build in the proximal tubule cells of C57BL/6 mice (Transgenic model of Cancer of the Kidney (TRACK) (1)) mimics the histological fluctuations found in early stage human ccRCC