alexa Synthesis of Diacylglycerol Analogs Bearing Photoaffinity Tags for Labelling Mammalian Diacylglycerol Kinase

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Synthesis of Diacylglycerol Analogs Bearing Photoaffinity Tags for Labelling Mammalian Diacylglycerol Kinase

Signaling lipids such as diacylglycerol (DAG), phosphatidic acid, and the phosphatidylinositol polyphosphates are site-specific ligands for protein binding partners. Herein, we report the apotheoses of our initial approach to the development of diverse probes which are vital for understanding lipid-protein interactions. When incorporated into liposomes, these probes reduce mammalian diacylglycerol kinase’s (DGK) enzymatic activity in a concentration, time, and light dependent manner.

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https://www.omicsonline.org/open-access/synthesis-of-diacylglycerol-analogs-bearing-photoaffinity-tags-for-labelling-2161-0444.1000015.php?aid=37073

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