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Among the most common of health problems, allergies afflict more than one of every six.These Inflammatory and allergic mediators in turn cause contraction of smooth muscle, itch, secretion of mucus, and vascular leakage. To minimize such effects H1 receptor antihistamines and the sympathomimetic decongestants are developed. Antihistamines were first used clinically 50 years ago. Their ability to cross the blood-brain barrier, cause varying degrees of sedation. The effects of antihistamines on psychomotor reflexes and driving skills, antihistamine-induced drowsiness, and the interaction of antihistamines with alcohol and tranquilizers are under review by researchers.