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Kawasaki disease, also known as Kawasaki syndrome, is an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed. The illness involves the skin, mouth, and lymph nodes, and most often affects kids under age 5. The cause is unknown, but if the symptoms are recognized early, kids with Kawasaki disease can fully recover within a few days. Untreated, it can lead to serious complications that can affect the heart. Kawasaki disease can't be prevented, but usually has telltale symptoms and signs that appear in phases. During the second phase, which usually begins within 2 weeks of when the fever started, the skin on the hands and feet may begin to peel in large pieces. This can even happen in children who have already been treated. A child also may have joint pain, diarrhea, vomiting, or abdominal pain. Untreated cases can lead to more serious complications, such as vasculitis.