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Multiple sclerosis (MS) is the prototypic neuroimmune disease, defined by neuroinflammation within the central nervous system (CNS) accompanied by demyelination and axonal disruption. Viral proteins, in particular glycosylated retrovirus envelope proteins, are potent inducers of inflammation with ensuing cell damage and death. Approximately 8% of the human genome is comprised of retrovirus-like sequences (retroelements), represented chiefly by human endogenous retroviruses (HERVs), which originated through germ-line infection by their exogenous ancestors during primate evolution.
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