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This perspective article constructs a global and molecular antiadiposity theory on evolutionary circadian rhythms of insulin-mediated appetite regulation. Insulin as a storage hormone with leading contributions to intermediary metabolism has been interacting with genetic diversity in different mammals. As demanded by the living environment, insulin stimulates high-performance cellular glucose and amino acids entry [1,2]. Ruminants, as sophisticated working models for studying most devastating diseases in humans, are differently diversified genetically. As such, much less glucose crosses into the portal vein in ruminants than in non-ruminants.
For More Information: https://www.omicsgroup.org/journals/evolutionary-coemergence-of-appetite-and-hormonal-rhythms-a-molecular-highway-to-overpass-obesity-2376-0214.1000e105.php?aid=31287
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