According to the “Chemotherapy Side-Effects” sheet of the National Cancer Institute, which is available to the public, 18 sideeffects are listed including memory problems and fatigue but not including heart problems . The author often noticed that when cancer patients receiving chemotherapy treatment were offered helpful instruction the patient did not follow because the patient could not remember the instruction. Patients receiving chemotherapy treatment often complain of feeling very tired with discomfort on the heart area. For these patients, when ECGs are taken, we often found a very slight abnormality in the rising part of the T wave of the ECG corresponding to “Vulnerable Period for Ventricular Fibrillation.” But, most cardiologists consider that the patient has no serious heart problems. When measuring the blood level of cardiac Troponin I levels in these patients, often they come back within normal limits or with slight increases. The question iswhat is happening to the brain and heart of these patients? Is there really no problem in the heart? When there is some evidence that only small part of heart or certain phase of ECGs has some problem, but current accepted ECG interpretation seems to have limitations of detecting them.As the consequences, no significant changes in the blood cardiac Troponin I levels and waveform and amplitude of ECG Voltage are expected.Final question is what factor of chemotherapy is worsening side effects.
Omura Y (2012) Important Clinical Implications of Side Effects of Chemotherapy for the Brain & Heart (Which are often Unrecognized) are often due to Overdose of Chemotherapy Medicine, and how to Prevent them. J Integr Oncol 1:e105.