alexa Pulmonary Hypertension Precedes Emphysema: Paradigm Shift or Artifact of Rodent Studies?

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Pulmonary Hypertension Precedes Emphysema: Paradigm Shift or Artifact of Rodent Studies?

Chronic Obstructive Pulmonary Disease (COPD) is often oversimplified as it was just chronic bronchitis. The patient is such depicted as a constantly coughing and heavily breathing victim of obstructed airways, who will find convenient relieve from bronchodilators. The fact that bronchodilators wear off and that COPD is progressively worsening reminds us of the other definition of COPD which is emphysema, and that this pathology is actually eating up the gas exchanging parts of the lungs, which basically consist of epithelial lined air and blood vessels. The fact that emphysema in contrast to chronic bronchitis is not treatable begs the question whether we have used the right approach for this disease and supports the view that emphysema and chronic bronchitis can be independent diseases.

 

Seimetz M, Weissmann N and Clauss M (2014) Pulmonary Hypertension Precedes Emphysema: Paradigm Shift or Artifact of Rodent Studies?. Angiol Open Access 2:e108

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