Objective: Decipher mechanisms that underlie cervical remodeling (CR) during pregnancy.
Design and population: Examine the proteomic profile of mice cervices in early and late pregnancy and verify data generated using Western Blot and real time PCR analysis. Main outcome measures: Identify signature proteins.
Results: In total, seventy three (73) signature proteins were identified and were found up regulated in pregnancy, namely proteins associated with: a) collagen presence and organization (4), notably biglycan and lumican, b) immune scavenging functions and c) cytoskeletal activity. These proteomic trends were verified through Western blot and real time PCR analysis.
Citation: Schwabe J, Donnelly SM, Jesmin S, Leppert P, Mowa CN (2014) A Proteomic Profile of Cervical Remodeling in Mice during Early and Late Pregnancy. J Steroids Horm Sci 5:123. doi: 10.4172/2157-7536.1000123