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The next big endeavor after the Human Genome Project is, of course, the Human Phenome Project, in other words, the ability to deduce the person’s phenotype from the known genome, transcriptome, epigenome, and other …omic data. While certain phenotypes are easily predicted based on simple genotype-phenotype relationships such as Mendelian traits, many phenotypes including physical appearance, disease susceptibility, and physiological profile of an organism are still beyond our grasp. Luckily, Pharmacogenomics works with much simpler phenotypes. The phenotype in a PGx study is a physiological reaction to a chemical stimulus, usually a medication. Therefore, a pharmacogenomic model is the first step toward predicting macro scale characteristics of an organism based on its genome.
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