Seven patients presented a specific renal lesion of rapidly progressive glomerulonephritis with myeloperoxidase anti-neutrophil cytoplasmic antibody. Rapidly progressive glomerulonephritis with myeloperoxidase anti-neutrophil cytoplasmic antibody can be associated with pulmonary hemorrhage and/or pulmonary interstitial fibrosis. The patients included three men and four women with a mean age of 62.4 years. All courses of renal lesions revealed rapidly progressive glomerulonephritis and the serum creatinine levels were 7.1 ± 3.9 mg/dl and the myeloperoxidase anti-neutrophil cytoplasmic antibody was 473 ± 471 EU before treatments. Steroid therapy was administered to all patients, immunosupressive agent to four and hemodialysis in six cases. Four patients experienced a pulmonary hemorrhage and died, but all of three patients with pulmonary interstitial fibrosis survived.
Citation: Sanai T, Hirakawa T, Mizumasa T, Koga H (2014) Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody Glomerulosclerosis Associated with Pulmonary Disorders. J Steroids Hormon Sci 5:145. doi: 10.4172/2157-7536.1000145