Several biomarkers have been proposed for detecting AD in its earliest stages, that is, in the predementia stage. In an attempt to find noninvasive biomarkers, researchers have investigated the feasibility of neuroimaging tools, such as MR, SPECT as well as neurophysiological measurements using EEG. Moreover, the increase of EEG alpha3/alpha2 ratio has been associated with AD-converters subjects with mild cognitive impairment (MCI). To study the association of EEG marker with specific cerebral blood flow changes in subjects with MCI.
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