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Central diabetes insipidus (CDI) is a disorder that is characterized by polyuria, polydipsia and the presence of hypotonic urine as a result of the inability to secrete or to synthesize vasopressin in the neurohypophyseal system [1]. The etiology of CDI comprises a variety of diseases that infiltrate and destroy the posterior pituitary, pituitary stalk, or hypothalamus. We report two young women with an acute onset of CDI, in whom magnetic resonance imaging (MRI) revealed a thickening of the pituitary stalk [2]. Langerhans cell histiocytosis (LCH) had been diagnosed as the cause of CDI in these two patients.