alexa The Burden of Human Osteoarthritis: Cell- and Gene-Based Therapies on the Horizon?

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

The Burden of Human Osteoarthritis: Cell- and Gene-Based Therapies on the Horizon?

"Osteoarthritis (OA) is a degenerative disease of the entire joint that affects millions of people worldwide, becoming one of the most prevalent and costly diseases of our societies. OA is a particularly complex, disabling condition, as many risk factors have been associated with its incidence (aging, trauma, metabolic conditions, and genetic background).

OA is mostly characterized by a gradual, irreversible degeneration of the articular cartilage showing a loss of major extracellular matrix (ECM) components (proteoglycans, type-II collagen), with concomitant changes in the subchondral bone and synovium. Disturbances in cartilage homeostasis are believed to play determining roles in the pathogenesis and progression of OA.

Proinflammatory cytokines (IL-1, TNF-α) and adipokines (leptin, adiponectin, resistin) locally produced by the inflamed synovium, infrapatellar fat pad, osteophytes, or by the chondrocytes themselves may all contribute to the pathophysiology of OA"

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords