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Mitochondria, the powerhouse of mammalian cells, vary in their number and function in different cell types with different energy demands. Mitochondria are semiautonomous organelles within cells that play an important role in cellular energy metabolism, free radical generation, and apoptosis. Mitochondria contain their own genome (mtDNA), which encodes a number of proteins critical for energy metabolism, particularly in oxidative phosphorylation.
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