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The basal ganglia-supplementary motor area (BG-SMA) loop is thought to be involved in a number of stereotypical and spontaneous behaviors including walking by inducing the circuitries of pattern generators in the brainstem and spinal cord. In Parkinson’s disease (PD), anticipatory postural adjustments (APA) during voluntary stepping were found to be reduced after the area over the SMA underwent 1-Hz repetitive transcranial magnetic stimulations. The severity of PD symptoms was negatively correlated with APA duration. Stepping performance was not affected with stimulation of the dorsolateral premotor cortex.
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