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http://www.ncbi.nlm.nih.gov/pubmed/25536166
Zinc finger nucleases (ZFNs) are engineered restriction enzymes designed to target specific DNA sequences within the genome. Assembly of zinc finger DNA-binding domain to a DNA-cleavage domain enables the enzyme machinery to target unique locus in the genome and invoke endogenous DNA repair mechanisms.
Courtesy: Jabalameli et al., 2015