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Increasing socio-political worries with antibiotic usage have led to inquiries of potential alternatives for food safety and growth elevation. Both live and spore based probiotics have earned marvelous attention as a viable control of enteric pathogens. Probiotics or direct-fed microbial and are comprised of a variable number of species and strains of beneficial bacteria known to have positive implications on poultry health and performance. Chickens and poultry for commercial production are hatched in a clean environment, hence delaying their colonization by healthy micro-flora. Under this near “sterile” environment, the intestinal tract of these newly hatched chickens and poultry provides a suitable ecological niche for any pathogen. Colonization of mucosal surfaces of newly hatched chickens with beneficial gut micro-flora is therefore a matter of significance. In this regard, the use of probiotic products enabling early rapid colonization of chickens with healthy adult gut micro-biota has been suggested