Immune checkpoints constitute a distinctive set of proteins that belong to the B7 family. The engagement of these transmembrane receptors with their ligands provides critical signals to inhibit T cell activation and promote for immune tolerance. Tumor and infected cells can hide from the immune system by overexpressing these proteins, leading to T cell exhaustion. Blocking these interactions emerged as a ’game changing’ approach in anticancer and antiviral immunotherapy.
For more details: https://www.omicsgroup.org/journals/immune-checkpoints-the-search-for-a-single-antiviralanticancer-magicbullet-2376-0419-1000e125.php?aid=44948