alexa Matrix Metalloproteinases

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Matrix Metalloproteinases

Meta Description: Matrix metalloproteinases are extracellular zinc-dependent endopeptidases which are capable of degrading all extracellular matrix components which is otherwise a complex net of proteins and carbohydrate polymers that are secreted by connective tissue cells.

Matrix metalloproteinases are extracellular zinc-dependent endopeptidases which are capable of degrading all extracellular matrix components which is otherwise a complex net of proteins and carbohydrate polymers that are secreted by connective tissue cells. These are expressed by fibroblasts, endothelial cells, tumor cells and a variety of immune cells.

The Matrix metalloproteinases family is divided into five subfamilies. Those are collagenases, gelatinases, stromelysins, matrilysins and membrane type metalloproteinases. Twenty five human matrix metalloproteinases have already described and the remaining new members have not yet been investigated. The levels of matrix metalloproteinases expression are relatively less in normal conditions, whereas their expression is increased by determined physiologic conditions such as extracellular matrix remodeling during embryogenesis, bone remodeling and tissue repair. The increased matrix metalloproteinases expression can be observed in several diseases, including neoplasms and arthritis.

 
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