Life is characterized by separation from the surroundings. Organisms are built out of cells, cells contain separate compartments. Compartmentalization is therefore an already existing principle in nature. Cells perform complex biosynthesis and transport within closed containers employing lipid membranes called vesicles. These natural systems served as a model system for encapsulation of pharmaceutical and cosmetic components. These naturally-derived lipid vesicles, so-called liposomes, showed significant success in their design and application in biotechnological applications due to their unique properties.