Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS), Tuberculosis (TB) and Diabetes mellitus (DM) were individually one of the top ten causes of mortality all over the world . Annual deaths caused by these diseases were 1.78 million, 1.34 million and 1.26 million respectively. Dreadfully, all together these three killers claim 4.38 million lives, which correspond to 7.7% of total deaths/annum. Among the three killers two are chronic communicable disease i.e., HIV and TB; and the other is chronic noncommunicable disease i.e., DM. The association between communicable and noncommunicable diseases were known for centuries but are neglected until recently. Intriguingly, in the recent past evidences were accumulating on the association between TB and DM, as well as HIV/ AIDS and DM, which gained importance to the communicable – noncommunicable disease association. Nevertheless, the HIV-TB link was well recognized since the beginning of HIV epidemic. Hence, this editorial is attempted to review the evidence and counter-evidence stating the association between these three deadly diseases in relation to aetiopathogenesis, diagnosis and management.