It takes several years, for a gene of interest in basic science to get into clinical trial. These developments are much hoped for but never are easy and certainly not fast. These steps usually involve many years of basic science research, financial support and yet no conclusion for a clinical trial. One of the genes, which climbed these steps very fast, is the mesoderm-inducing gene and T-box transcription factor ‘Brachyury’. Brachyury was not studied extensively in cancer until the recent years. Its role in the cancer was merely known until very recently.