alexa Essential Oil Composition and Cytotoxic Activity of Libanotis transcaucasica Schischk. from Iran

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Recommended Conferences

  • 11th International Conference on Pharmacoepidemiology and Clinical Research
    July 06-08, 2017, Kualalumpur, Malaysia
  • International Conference on Microbial Ecology & Eco Systems
    September 18-20, Toronto, Ontario, Canada

Subject wise Global Events

Essential Oil Composition and Cytotoxic Activity of Libanotis transcaucasica Schischk. from Iran

Background: Libanotis transcaucasica Schischk. belonging to the family of Apiaceae is a perennial plant that is distributed in Europe, northwest of Iran and also Caucasia.

Purpose: Due to the interest on development of drugs from natural origins, we studied the components and cytotoxic activity of essential oil from L. transcaucasica.

Methods: The essential oil of L. transcaucasica was obtained by hydro distillation of its air-dried aerial parts and was analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Cytotoxic activity of the essential oil was assessed on four human cancer cell lines (HeLa, LS180, MCF-7 and Raji).

Results: The yield of oil was 0.9% (w/w) and it had yellow color. Fifty-four compounds in L. transcaucasica representing 84.0% of the oil components were identified. Germacrene B (20.2%) was the most abundant compound in this oil, followed by isospathulenol (11.0%), germacrene D (9.2%) and kessane (5.5%). The volatile oil displayed weak to moderate cytotoxic activity in all evaluated human cancer cell lines (IC50 =0.9-0.2 mg/ml). The highest and the lowest cytotoxic effects were observed on Raji and LS180 cell lines, respectively.

Conclusion: Sesquiterpene hydrocarbons were identified as the main components of the essential oil (48.3%). The cytotoxic activity observed in the essential oil may be contributed to the existence of this group of hydrocarbons in the plant.

Citation: Shahabipour S, Firuzi O, Asadollahi M, Miri M, Javidnia K (2013) Essential Oil Composition and Cytotoxic Activity of Libanotis transcaucasica Schischk. from Iran. Nat Prod Chem Res 1:108. doi: 10.4172/2329-6836.1000108

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords