alexa Nephrology: Urinary Biomarkers IGFBP-7 and TIMP-2 for AKI Risk Stratification: Are we there yet?

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Nephrology: Urinary Biomarkers IGFBP-7 and TIMP-2 for AKI Risk Stratification: Are we there yet?

Improving Global Outcomes (KDIGO) recently published practice guidelines for identification and treatment of patients with acute kidney injury (AKI). One important recommendation from the KDIGO guidelines was the development of biomarkers that identify AKI prior to elevations of serum creatinine, which can take days to manifest. AKI is one of the most common organ dysfunctions in critically ill patients which adversely impacts short- and long-term clinical outcomes. It is frequently observed in patients after cardiac surgery (CS) involving cardiopulmonary bypass (CPB). Early diagnosis of AKI, preferably within 24 hours after ICU admission, is likely pivotal to the development of effective therapies. Traditional biomarkers like creatinine are late indicators of AKI, delaying diagnosis by days. For full article: https://www.omicsonline.org/open-access/urinary-biomarkers-igfbp7-and-timp2-for-aki-risk-stratification-are-we-there-yet-2161-0959-1000200.php?aid=50778

 
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