Patients with type 1 diabetes produce little or no insulin due to an autoimmune destruction of the β-cell mass. Several decades ago, it has been demonstrated that diabetic rats could restore normoglycemia after transplantation with isogeneic islets . This observation resulted in whole-pancreas or islet transplantation to treat patients with type 1 diabetes . Nevertheless, several hurdles still need to be resolved before this strategy can be introduced for routine use. The major problem is the scarcity of transplantable islets. Therefore, several groups are currently trying to generate large numbers of β-cells in vitro from stem cells of both embryonic and adult origin for clinical utility.
Citation: Declercq J, Creemers JW (2012) Replenishing a Balanced Mixture of Hormone Producing Cells: A Necessary Component in the Stem Cell Based Therapy for Diabetes? J Steroids Horm Sci 3:e111. doi:10.4172/2157-7536.1000e111