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Despite the well-established links between signalling and transcriptional activity, little is known about how transcriptional activators are regulated after tumorigenesis is triggered. An obvious mechanism to limit the expression time of an activator is to destroy it via the ubiquitin-proteasome pathway. Ideally, activator turnover should be tied to its efficiency in driving transcription. The F-box protein, FBXW7, is an E3 ubiquitin ligase molecule which targets multiple transcriptional activators and oncoproteins for degradation.
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