Reactive oxygen species have been implicated in seizure-induced neurodegeneration, and there is a correlation between free radical level and scavenger enzymatic activity in the epilepsy. It has been suggested that pilocarpineinduced seizures is mediated by an increase in oxidative stress. Current research has found that antioxidant may provide, in a certain degree, neuroprotection against the neurotoxicity of seizures at the cellular level. Crysophanol has numerous nonenzymatic actions and is a powerful liposoluble antioxidant.
Citation: dos Santos RN, Silva MGV, de Freitas RM (2011) Crysophanol Effects on Lipid Peroxidation Levels and Catalase Activity in Mice Hippocampus after Pilocarpine-induced Seizures. J Cell Sci Ther 2:104.