Many behaviors in children diagnosed with autism spectrum disorder (ASD) resemble fight-or-flight avoidance responses resulting from habitual states of fear, possibly induced by sensory processing issues, causing on-going stress and deregulation of systemic pacing. This study hypothesized that patterned, tempo-based, rhythm interventions, at 60-beats per minute (pbm), can regulate and induce systemic pacing, reduce repetitive anxiety behaviors and enable focus and calm in persons with ASD. Eight-week pilot study investigated the influence of four sensorimotor rhythm interventions for habituation (entrainment) of systemic inner rhythms, pacing, stress, anxiety, and repetitive behavior reduction, ultimately yielding eye- contact, attention, motor planning, and memory. Six subjects ( n = 6) ages 8–12, with ASD and minimal expressive language, were treated in 45-minute weekly one-on-one music therapy session, over eight weeks. A rating scale tracked responses and progress in vivo per session, and on video-tape.