Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term co-existence of host and pathogen. Tuberculosis (TB) patients were not visiting heath facility but transmit disease to healthy individuals in the community for longer time in Ethiopia. This study was focused to determine the prevalence of TB among patients at Dilla Referral Hospital and exploring predisposing factor to TB Disease. The study was conducted at Dilla Referral Hospital which found in Gedeo zone. The date ranged from year 2008-2014 and about 5572 patients were examined for tuberculosis infection. According to respondents response, majority of respondents of males 44 (27.85%) were calmed for availability of drugs and equipments for TB, whereas the least number of respondents of females 14 (8.86%) were calmed for availability of drugs and equipments for TB. The most infected individuals with TB at 2012 and 2013 year, at the age of 6-20 years old, 89 (38.70%) and 88 (38.77%) respectively. The males infected with TB disease 59.84% , 59.38% , 58.99% , 58.90% , 58.75% , 58.15% , 56.52% were 2010, 2009, 2014, 2008, 2011, 2013 and 2012 respectively.