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The study was conducted to determine the insecticidal and physiological activity of essential oil from Artemisia annua L. on Indial meal moth Plodia interpunctella (Hübner) in laboratory condition. The yellowish oil of wormwood Artemisia annua L. was diluted in acetone and different concentrations (15%, 11%, 8%, 5.5% and 4%) were assayed on 17 days old larvae.\