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Dexlansoprazole is an outstanding proton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide.
Citation: Zhou Z, Li L, Yan N, Du L, Sun C, et al. (2015) Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR. Med chem 5:235-240. doi: 10.4172/2161-0444.1000270