alexa The Effect of Intravenous Immunoglobulin (IVIG) on In vitro Activation of Circulating Neutrophils

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The Effect of Intravenous Immunoglobulin (IVIG) on In vitro Activation of Circulating Neutrophils

The application of IVIG for cancer treatment is associated with the problem of variable patient’s response to IVIG, which might result from the peculiarities of neutrophil’s activation. Individual variations in the response to IVIG treatment can be elucidated by the comparison of CBA and C57BL/6 mouse strains. These two strains are considered as contrasting ones regarding function of their immune system. Here we studied zymosan-induced activation of circulating neutrophils from CBA and C57BL/6 mice developing fibrosarcoma. The activity of circulating neutrophils changes with the tumor development via the mechanisms, which depend on the strain type. These mechanisms are sensitive to IVIG and the effects of IVIG vary also with the stage of tumor growth. Developing fibrosarcoma induced priming of neutrophils in both mouse strains, mainly by calcium-dependent pathway. OZ-stimulated neutrophils from CBA were less active compared to C57BL/6, and implicated calcium-independent pathways even at day 7 of tumor development.

 
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