Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. NAFLD involves a spectrum of conditions that include pure steatosis without inflammation, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Insulin resistance (IR) plays a main role in the pathophysiology of NAFLD by causing lipid accumulation in the hepatocytes, which may be followed by lipid peroxidation, production of reactive oxygen species and consequent inflammation.
Citation: Armiliato GNA, Ferolla SM, Ferrari TCA, Couto CA (2015) High-fructose Intake in Obesity-related Nonalcoholic Fatty Liver Disease. J Gastrointest Dig Syst 5:281. doi: 10.4172/2161-069X.1000281