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Adult T-cell leukemia/lymphoma (ATL) is one of aggressive mature T-cell malignancies. CD30 is a cell membrane protein expressed on activated T-cell. While a limited number of ATL cells show the CD30 expression, high levels of soluble CD30 (sCD30) are detected in serum of ATL patients. It is known that a disintegrin and metalloproteinase (ADAM)10 and ADAM17 are ubiquitously expressed in peripheral leukocytes including T cells.