Adult T-cell leukemia/lymphoma (ATL) is one of aggressive mature T-cell malignancies. CD30 is a cell membrane protein expressed on activated T-cell. While a limited number of ATL cells show the CD30 expression, high levels of soluble CD30 (sCD30) are detected in serum of ATL patients. It is known that a disintegrin and metalloproteinase (ADAM)10 and ADAM17 are ubiquitously expressed in peripheral leukocytes including T cells.
Citation: Takemoto S, Pornkuna R, Nishioka C (2015) Serum Soluble CD30 Levels to Detect Activation and Aggression Status of Adult T-Cell Leukemia/Lymphoma Cells. J Hematol Thrombo Dis 3:205. doi: 10.4172/2329-8790.1000205