alexa Two Functional Guanidine Groups Are Responsible For the Biological Activity of Streptomycin and Functionally Equivalent Molecules

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Two Functional Guanidine Groups Are Responsible For the Biological Activity of Streptomycin and Functionally Equivalent Molecules

The guanidine-containing compounds constitute a very important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases as well as disinfecting agents. Several molecules possesses two guanidine groups as streptomycin, dihydrostreptomycin, triethylenetetramine, bis-3-aminoproylamine, guanidine hydrochloride, and spermine tetra-hydrochloride. The presence of these 2 functional guanidine groups within a non-polymeric hydrophilic molecular system was suspected to be the chemical structure of streptomycin implicated in the interaction with proteins [1]. This interaction takes place through hydrogen bond transfer among the 2 guanidine groups on streptomycin and the amino-acids of one or several prion peptides. The addition of low concentration of streptomycin to a constant amount of non-soluble fraction of the infectious prion protein (PrPsc) followed by electrophoresis on polyacrylamide gel and immuno detection revealed an increase in the apparent molecular mass of each of the three bands and this increase of the protein molecular mass was proportional to the added streptomycin quantity. When higher streptomycin concentration were added and incubated with PrPsc for one hour at 37°C aggregation and flocculation of the prion protein occurred due to cross-linking by such a proportionally small streptomycin molecule and the PrPsc isoforms or fragments

 

Citation: Moussa A (2014) Two Functional Guanidine Groups Are Responsible For the Biological Activity of Streptomycin and Functionally Equivalent Molecules. J Chromatogr Sep Tech 5:e126. doi: 10.4172/2157-7064.1000e126

 
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