alexa The Roles of Membrane Transporters on the Oral Drug Absorption

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The Roles of Membrane Transporters on the Oral Drug Absorption

Oral drug absorption is usually dependent on drug’s physicochemical properties, formulation design and physiological conditions of gastrointestinal tract [1]. It is well known that physicochemical properties of drugs, like molecular weight, crystal structure, lipophilicity, pKa could generally determine the absorption mechanism [2]. Physiological conditions of gastrointestinal tract, i.e., expression level of drug metabolizing enzymes (polymorphism), empty/transit of GI tract, food effect, and drug-drug interaction caused by induction or inhibition of metabolism all contributed to the rate and extent of oral drug absorption [3,4].

 

Yang Z (2013) The Roles of Membrane Transporters on the Oral Drug Absorption. J Mol Pharm Org Process Res 1:e102.

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